8/18/2023 0 Comments Pneumatic leg compression![]() ![]() Collectively, these data indicate that IPC improves exercise tolerance in a model of peripheral arterial insufficiency in part by enhancing blood flow to collateral-dependent tissues. Intermittent Pneumatic CompressionDevices The vast majority of devices that are considered mechanicalinvolve a pneumatic compression device supplying air to legand/or foot chambers that are intermittently inflated with airto a preselected pressure either in a uniform or sequential fash-ion. Capillary contacts per fiber and citrate synthase activity were not significantly altered by IPC treatment. Compared with sham-treated controls, blood flow measured with isotope-labeled microspheres during in situ contractions tended to be higher in IPC-treated animals in muscles composed of predominantly fast-twitch white fibers, such as the plantaris (∼93%, P = 0.02). Marked increases in treadmill exercise tolerance (∼33%, P < 0.05) and improved muscle performance in situ (∼10%, P < 0.05) were observed in IPC-treated animals. A third group of nonligated rats was also studied. Animals were anesthetized daily and exposed to 1-h sessions of bilateral IPC or sham treatment for 14-16 consecutive days. Male Sprague-Dawley rats were subjected to bilateral ligation of the femoral artery and randomly allocated to treatment or sham groups. We tested the hypothesis that 2 wk of daily application of IPC enhances exercise tolerance by improving blood flow and promoting angiogenesis in skeletal muscle in a model of peripheral arterial insufficiency. Application of intermittent pneumatic leg compressions (IPC) is regarded as a promising noninvasive approach to treat this condition, but the clinical efficacy, as well the mechanistic basis of action of this therapy, remain poorly defined. Despite the escalating prevalence in the aging population, few therapeutic options exist to treat patients with peripheral arterial disease.
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